Codeine is a drug that until recently was widely used in children. It was endorsed by the WHO as the 2nd step on the analgesic ladder for cancer pain. Recently it's safety and efficacy have been called into question. This article discusses the pharmacology underpinning it's action in children, how this relates to prescribing as well as the practical issues and the most recent regulatory framework surrounding it's use.
Andrzejowski, P. & Carroll. 2016. Codeine in paediatrics: pharmacology, prescribing and controversies. Archives of Disea51se in Childhood. 101 p 148 - 150
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