This Australian research is a retrospective review of the use of methadone in 16 children with life-limiting illnesses. Efficacy, dosing and side effect profiles were analysed. Fifteen patients had improvements in their analgesia with minimal observed adverse effects. Analysis of dosing and ratios indicated that an individualized approach is required. The study concluded that specialist assistance with dosing is recommended and further research, including prospective and pharmacokinetic studies also recommended.
Mott, C. et al. Methadone for analgesia for children with life-limiting illness: experience from a tertiary children's health service. Children 5 (86) online.
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