As death approaches, patients are at their most frail, but an increasing symptom burden often necessitates an increase in medications. This study used case notes from 266 adult patients referred to specialist palliative care. The study found that the mean number of medications prescribed was 10.8 with 72% of patients at risk of one or more drug interaction. The authors conclude some drug interactions may be recognised as an acceptable risk, but more research is required to improve recognition of potential drug interactions and the rates of morbidity or associated mortality associated with this. Greater use of computerised prescribing software and closer liaison with clincal pharmacists is recommended.
Morgan, N. A., Rowett, D. & Currow, D. 2015. Analysis of drug interactions at the end of life. BMJ Supportive and Palliative Care. 5 (3) p 281-286.
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